Transcription profiling of human prostate cancer primary cultures

ABSTRACT: The histopathological and molecular heterogeneity of prostate cancer and the limited availability of human tumor tissue make unraveling the mechanisms of prostate carcinogenesis a challenging task. Our goal was to develop an ex vivo model that could be reliably utilized to define a prognostic signature based on gene expression profiling of cell cultures that maintained the tumor phenotype. To this end, we derived epithelial cultures from tissue explanted from 59 patients undergoing radical prostatectomy or cistoprostatectomy because of Prostate Benign Hyperplasia/Prostate Cancer or Bladder Carcinoma. Patient selection criteria were absence of hormonal neo-adjuvant treatment before surgery and diagnosis of clinically localized disease. Using this unique experimental material we analyzed exp

ORGANISM(S): Homo sapiens

SUBMITTER: Antonella Farsetti 

PROVIDER: E-GEOD-3868 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress