Genome-wide copy number variant analysis in inbred lines of chickens with different susceptibility to MarekM-bM-^@M-^Ys disease

ABSTRACT: MarekM-bM-^@M-^Ys disease virus (MDV) is an oncovirus causing tumor disease known as MarekM-bM-^@M-^Ys disease (MD) in chicken. Breeding of chickens genetically resistant to MD is considered a vital augment to better control MD. To find the mechanism underlying the genetic resistance to MD, a genomic structural variation, copy number variation (CNV), was examined in inbred MD-resistant and -susceptible chicken lines by using the comparative genomic hybridization (CGH) technique. A total of 45 copy number variation regions (CNVRs) were found spanning across 3,297,038 bp in length of the chicken genome in 4 lines of chickens. Ten CNVRs were selectively confirmed with quantitative real-time PCR. The comparison between the resistant and susceptible chicken lines revealed 28 differentially pres

ORGANISM(S): Gallus gallus

SUBMITTER: Juan Luo 

PROVIDER: E-GEOD-38689 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress