Translational regulation of Anopheles gambiae mRNAs in the midgut during Plasmodium falciparum infection

ABSTRACT: Malaria is caused by Plasmodium parasites, which are transmitted via the bites of infected Anopheline mosquitoes. Midgut invasion is a major bottleneck for Plasmodium development inside the mosquito vectors as a rapidly responding immune system recognizes ookinetes and recruits killing factors from the midgut and surrounding tissues, dramatically reducing the population of invading ookinetes before they can successfully traverse the midgut epithelium. Understanding molecular details of the parasite-vector interactions requires precise measurement of nascent protein synthesis in the mosquito during Plasmodium infection. Current expression profiling primarily monitors alterations in steady-state levels of mRNA, but does not address the equally critical issue of whether the proteins encoded b

ORGANISM(S): Anopheles gambiae

SUBMITTER: Jinsong Zhu 

PROVIDER: E-GEOD-38707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress