High-throughput microRNA (miRNAs) arrays in pancreatic cancer

ABSTRACT: Background: Only a subset of radically-resected pancreatic ductal adenocarcinoma (PDAC) patients benefit from chemotherapy, and identification of novel prognostic factors is warranted. Recently miRNAs emerged as diagnostic biomarkers and innovative therapeutic targets, while high-throughput arrays are opening new opportunities to evaluate whether they can also predict clinical outcome. The present study evaluated whether comprehensive miRNA expression profiling correlated with overall survival (OS) in resected PDAC patients. Methodology/Principal Findings: High-resolution miRNA profiles were obtained with the Toray’s 3D-GeneTM miRNA chip, detecting more than 1200 types of human miRNA. RNA was isolated from paraffin-embedded primary tumors of 26 radically resected stage-pT3N1 homogeneous

ORGANISM(S): Homo sapiens

SUBMITTER: Elisa Giovannetti 

PROVIDER: E-GEOD-38781 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress