Id2a knockdown in zebrafish retina

ABSTRACT: During vertebrate retinogenesis, the precise balance between retinoblast proliferation and differentiation is spatially and temporally regulated through a number of intrinsic factors and extrinsic signaling pathways. Moreover, there are complex gene regulatory network interactions between these intrinsic factors and extrinsic pathways, which ultimately function to determine when retinoblasts exit the cell cycle and terminally differentiate. We recently uncovered a cell non-autonomous role for the intrinsic HLH factor, Id2a, in regulating retinoblast proliferation and differentiation, with Id2a-deficient retinae containing an abundance of proliferative retinoblasts and an absence of terminally differentiated retinal neurons and glia. Here, we report that Id2a function is necessary and suf

ORGANISM(S): Danio rerio

SUBMITTER: Taejoon Kwon 

PROVIDER: E-GEOD-38786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress