Somatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [methylation27]

ABSTRACT: Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated genetic and epigenetic (DNA methylation and chromatin) profiling. We found that the basal-like trait is generally dominant and it is largely defined by epigenetic repression of luminal transcription factors. Definition of super-enhancers highlighted a core program common in luminal cells but high degree of heterogeneity in basal-like breast cancers that correlates with clinical outcome. We also found that protein extracts of basal-like cells is sufficient to induce luminal-to-basal phenotypic swi

ORGANISM(S): Homo sapiens

SUBMITTER: Kornelia Polyak 

PROVIDER: E-GEOD-38791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress