Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Differential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes

ABSTRACT: Analysis of microRNA expression in vastus lateralis muscle biopsies from 11 genetically identical twin pairs discordant for type 2 diabetes. This eliminates the influence of genotype and leads to the identification of microRNAs that are exclusively influenced by environmental (non-genetic) factors. Total RNA containing microRNAs were obtained from muscle biopsies (vastus lateralis) from genetically identical twin pairs (n=11 pairs). All twin pairs were discordant in respect to their glucose tolerance; thus, one twin has diabetes whereas the co-twin has either normal or impaired glucose tolerance.

ORGANISM(S): Homo sapiens

SUBMITTER: jette bork-jensen 

PROVIDER: E-GEOD-38835 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Aims/hypothesis</h4>We aimed to identify microRNAs (miRNAs) associated with type 2 diabetes and risk of developing the disease in skeletal muscle biopsies from phenotypically well-characterised twins.<h4>Methods</h4>We measured muscle miRNA levels in monozygotic (MZ) twins discordant for type 2 diabetes using arrays. Further investigations of selected miRNAs included target prediction, pathway analysis, silencing in cells and association analyses in a separate cohort of 164 non-diabetic MZ a  ...[more]

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