Expression evolution in gene groups: Inferring non-neutral regulatory change in pathways from transcriptional profiling data
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae x Saccharomyces mikatae
SUBMITTER: Yulia Mostovoy
PROVIDER: E-GEOD-38875 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Inferring evolutionary histories of pathway regulation from transcriptional profiling data.
Schraiber Joshua G JG Mostovoy Yulia Y Hsu Tiffany Y TY Brem Rachel B RB
PLoS computational biology 20131010 10
One of the outstanding challenges in comparative genomics is to interpret the evolutionary importance of regulatory variation between species. Rigorous molecular evolution-based methods to infer evidence for natural selection from expression data are at a premium in the field, and to date, phylogenetic approaches have not been well-suited to address the question in the small sets of taxa profiled in standard surveys of gene expression. We have developed a strategy to infer evolutionary histories ...[more]
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