Subtherapeutic antibiotics alter the murine colonic microbiome and early life adiposity

ABSTRACT: Early life exposure to antibiotics alters the gut microbiome. These alterations lead to changes in metabolic homeostasis and an increase in host adiposity. We used microarrays to identify metabolic genes that may be up- or down-regulated secondary to antibiotic exposure. Low dose antibiotics have been widely used as growth promoters in the agricultural industry since the 1950’s, yet the mechanisms for this effect are unclear. Because antimicrobial agents of different classes and varying activity are effective across several vertebrate species, we hypothesized that such subtherapeutic administration alters the population structure of the gut microbiome as well as its metabolic capabilities. We generated a model of adiposity by giving subtherapeutic antibiotic therapy (STAT) to young mice

ORGANISM(S): Mus musculus

SUBMITTER: Jiri Zavadil 

PROVIDER: E-GEOD-38880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress