Lack of genetic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases

ABSTRACT: Lymph-node (LN) metastases predict for high recurrence rates in breast cancer patients. Eradication of micro-metastatic tumor cells is the primary goal of adjuvant systemic treatment. Decisions regarding systemic treatment depend largely on primary tumor characteristics rather than on characteristics of their LN metastases. However, it remains unclear to what extent LN metastases, having already metastasized locally, resemble their primary breast tumors and as such will be eradicated by the systemic therapy chosen. In this study we investigated the genetic differences between primary breast cancers and their paired LN metastases using array comparative genomic hybridization analyses on a high resolution 720K Nimblegen platform. Thus far, no metastasis-specific genomic aberrations have been

ORGANISM(S): Homo sapiens

SUBMITTER: Christiaan Klijn 

PROVIDER: E-GEOD-38888 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress