Gene expression profiling of lung tissues from patients with combined pulmonary fibrosis and emphysema

ABSTRACT: Combined pulmonary fibrosis and emphysema (CPFE) is characterized by upper-lobe emphysema combined with lower-lobe fibrosis and a high prevalence of pulmonary hypertension. The aim of this study was to measure and analyze gene expression profiles in the lungs of CPFE patients. The results showed that the expression profiles of the fibrotic and emphysematous lesions were remarkably different in terms of function. Genes related to immune system, structural constituents of cytoskeleton, and cellular adhesion were overexpressed in fibrotic lesions, while genes associated with cellular fraction, cell membrane structures, vascular growth and biology, second-messenger-mediated signaling, and lung development (all processes that contribute to the destruction and repair of cells, vessels, and lung)

ORGANISM(S): Homo sapiens

SUBMITTER: Masayuki Hanaoka 

PROVIDER: E-GEOD-38934 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress