VSL#3 protects against development of visceral pain in the neonatal maternal separation model: A whole genome microarray study

ABSTRACT: Background & Aims: Irritable bowel syndrome (IBS) is a disorder characterized by chronic abdominal pain and is linked to post-inflammatory and stress-correlated factors that cause changes in the perception of visceral events. Increased evidence indicates that probiotic bacteria may be useful in treating IBS. Our aims were to evaluate the efficacy of treatment with VSL#3, a mixture of 8 probiotic bacteria strains, in the neonatal maternal separation (NMS)-induced visceral hypersensitivity rat model and to determine whether it modulates the colonic expression of pain-related genes. Methods: Male NMS pups were treated orally with placebo or VSL#3 at days 3-60, while normal, not separated rats were used as control. After 60 days from birth, perception of painful sensation induced by colo

ORGANISM(S): Rattus norvegicus

SUBMITTER: Stefano Fiorucci 

PROVIDER: E-GEOD-38942 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress