FS001: Aberrant gene expression in dogs with portosystemic shunts

ABSTRACT: Background: Congenital portosystemic shunts are developmental anomalies of the vascular system that cause portal blood to bypass the liver. Large-breed dogs are reported to have a predisposition for intrahepatic portosystemic shunts (IHPSS) and small-breed dogs a predisposition for extrahepatic portosystemic shunts (EHPSS). While the physiological consequences of the two types of shunt are identical, the metabolic pathways involved are probably different. The aim of this study was to gain insight into the metabolic pathways involved in the different types of portosystemic shunting. Results: Microarray analysis of mRNA expression in liver tissue from dogs with EHPSS and IHPSS revealed that the expression of 26 genes was altered in either IHPSS or EHPSS samples compared with that in liver sa

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Marian Groot Koerkamp 

PROVIDER: E-GEOD-39005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress