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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from mouse skeletal muscle

ABSTRACT: We generated skeletal muscle-specific knockout mice lacking the transcription factor Yin Yang 1 (YY1) and analyzed expression patterns in the skeletal muscle these mice. We used microarrays to detail the global programme of gene expression regulated by YY1. Wild type or knockout mice at 6 months were sacrificed and the soleus was isolated for RNA extraction.

ORGANISM(S): Mus musculus

SUBMITTER: Pere Puigserver

PROVIDER: E-GEOD-39009 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Defective mitochondrial morphology and bioenergetic function in mice lacking the transcription factor Yin Yang 1 in skeletal muscle.

Blättler Sharon M SM Verdeguer Francisco F Liesa Marc M Cunningham John T JT Vogel Rutger O RO Chim Helen H Liu Huifei H Romanino Klaas K Shirihai Orian S OS Vazquez Francisca F Rüegg Markus A MA Shi Yang Y Puigserver Pere P

Molecular and cellular biology 20120618 16

The formation, distribution, and maintenance of functional mitochondria are achieved through dynamic processes that depend strictly on the transcription of nuclear genes encoding mitochondrial proteins. A large number of these mitochondrial genes contain binding sites for the transcription factor Yin Yang 1 (YY1) in their proximal promoters, but the physiological relevance is unknown. We report here that skeletal-muscle-specific YY1 knockout (YY1mKO) mice have severely defective mitochondrial mo ...[more]

PMID: 22711985

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Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [BAT]

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2015-11-10 | E-GEOD-68429 | biostudies-arrayexpress

Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity [IWAT]

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Brown Adipose YY1 Deficiency Activates Expression of Secreted Proteins Linked to Energy Expenditure and Prevents Diet-Induced Obesity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-11-10 | E-GEOD-68443 | biostudies-arrayexpress

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Transcription profiling of human lung epithelial cells ollowing oncogenic KRAS expression and TBK1 suppression or infection with oncogenic KRAS (G12V) - SuperSeries

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2009-10-31 | E-GEOD-17671 | biostudies-arrayexpress

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2009-11-15 | E-GEOD-17643 | biostudies-arrayexpress

Transcription profiling of mouse Jardine SIDS Model

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2010-06-09 | E-MEXP-2189 | biostudies-arrayexpress

The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface

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