Gene expression profiling of M. mulatta (Rhesus macaques) infected with H1N1 and pH1N1 influenza

ABSTRACT: Annually, influenza A viruses circulate the world causing wide-spread sickness, economic loss, and death. One way to better defend against influenza virus-induced disease may be to develop novel host-based therapies, targeted at mitigating viral pathogenesis through the management of virus-dysregulated host functions. However, mechanisms that govern aberrant host responses to influenza virus infection remain incompletely understood. We previously showed that the pandemic H1N1 virus influenza A/California/04/2009 (H1N1; CA04) has enhanced pathogenicity in the lungs of cynomolgus macaques relative to a seasonal influenza virus isolate (A/Kawasaki/UTK-4/2009 (H1N1; KUTK4)). Here, we used microarrays to identify host gene sequences that were highly differentially expressed (DE) in CA04-infecte

ORGANISM(S): Macaca mulatta

SUBMITTER: Jason Shoemaker 

PROVIDER: E-GEOD-39018 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress