Deposition of histone variant H2A.Z within gene bodies regulates responsive genes

ABSTRACT: The regulation of eukaryotic chromatin relies on interactions between many epigenetic factors, including histone modifications, DNA methylation, and the incorporation of histone variants. H2A.Z, one of the most conserved but enigmatic histone variants that is enriched at the transcriptional start sites of genes, has been implicated in a variety of chromosomal processes. Recently, we reported a genome-wide anticorrelation between H2A.Z and DNA methylation, an epigenetic hallmark of heterochromatin that has also been found in the bodies of active genes in plants and animals. Here, we investigate the basis of this anticorrelation using a novel h2a.z loss-of-function line in Arabidopsis thaliana. Through genome-wide bisulfite sequencing, we demonstrate that a loss of H2A.Z in Arabidopsis does

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Toshiro Nishimura 

PROVIDER: E-GEOD-39045 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress