Thrombocythemic Platelets microRNA Profiling

ABSTRACT: Post-transcriptional and translational controls mediated by microRNAs (miRNA) regulate diverse biological processes and disease. We systematically dissected regulatory effects of miRNAs relevant to megakaryocytopoiesis and platelet biology by analyzing expression patterns in 79 subjects with thrombocytosis and healthy controls, and integrated these data with transcriptomic and proteomic platforms. We identified and validated a unique 21-miRNA genetic fingerprint associated with thrombocytosis, and demonstrated that a discrete 3-member subset effectively defines ET phenotypes. The genetic signature includes functional guide and passenger strands of the previously-uncharacterized miR 490 (5p and 3p), both of which displayed restricted, low-level expression in megakaryocytes/platelets (com

ORGANISM(S): Homo sapiens

SUBMITTER: Xiao Xu 

PROVIDER: E-GEOD-39046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress