Adaptively evolved yeast mutants on galactose shows trade-offs in carbon utilization on glucose.

ABSTRACT: Exploring molecular details of carbon utilization trade-offs in galactose-evolved yeast Adaptively evolved yeast mutants on galactose for around 400 generations showed diminished growth and carbon uptake rates on glucose. Genome-scale approaches were applied to characterize the molecular genetic basis of these trade-offs in carbon source utilization. Engineered mutants showing trade-offs in a specific carbon uptake rate between both carbons were used as controls. The transcriptional responses of the evolved mutants were almost identical during growth on both carbon sources. These carbon-independent conserved patterns were clearly observed in specific pathways and genes. Up-regulation of PGM2, a confirmed beneficial genetic change for improving galactose utilization was preserved on both c

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Kuk-Ki Hong 

PROVIDER: E-GEOD-39065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress