High-resolution genome-wide copy number analysis of pre-invasive mucinous ovarian tumours

ABSTRACT: Introduction: Mucinous tumors are the second most common form of epithelial ovarian tumor, yet the cell of origin for this histological sub-type remains undetermined. While these tumors are thought to arise through a stepwise progression from benign cystadenoma to borderline tumor to invasive carcinoma, few studies have attempted to comprehensively characterize the genetic changes specific to this subtype or its precursors. Methods: To explore the spectrum of genomic alterations common to mucinous tumors we performed high resolution genome-wide copy number analysis, mutation screening by Sanger sequencing and immunohistochemistry on a series of primary ovarian mucinous cystadenomas (n=20) and borderline tumors (n=22). Results: Integration of copy number data, targeted mutation screening

ORGANISM(S): Homo sapiens

SUBMITTER: Sally Hunter 

PROVIDER: E-GEOD-39076 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress