Gene expression-based, inflammatory response prediction by bronchial epithelial cell line treated with signal peptide of eosinophil cationic protein

ABSTRACT: Background Eosinophil cationic protein is a clinical asthma biomarker that would be released into blood, especially gathered in bronchia. The signal peptide of eosinophil cationic protein (ECPsp) plays an important role in translocating ECP to the extracellular space. We previously reported that ECPsp inhibits microbial growth and regulates the expression of mammalian genes encoding tumor growth factor-a (TGF-a) and epidermal growth factor receptor (EGFR). Results In the present study, we first generated a DNA microarray dataset, which showed that ECPsp upregulated proinflammatory molecules, including chemokines, interferon-induced molecules, and Toll-like receptors. The levels of mRNAs encoding CCL5, CXCL10, CXCL11, CXCL16, STAT1, and STAT2 were increased in the presence of ECPsp by 2.07-

ORGANISM(S): Homo sapiens

SUBMITTER: Hao-Teng Chang 

PROVIDER: E-GEOD-39122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress