Multiple DNA repair pathways collectively protect against DNA damage-induced replicative aging.

ABSTRACT: We demonstrate that transcriptomic profiling of the NER mutant ercc-1 offers better understanding of the complex phenotypes of ercc-1 deficiency in C. elegans, as it does in mammalian models. There is a transcriptomic shift in ercc-1 mutants that suggests a stochastic impairment of growth and development, with a shift towards a higher proportion of males in the population. Extensive phenotypic analyses confirm that NER deficiency in C. elegans leads to severe developmental and growth defects and a reduced replicative lifespan, although post-mitotic lifespan is not affected. Results suggest that these defects are caused by an inability to cope with randomly occurring DNA damage, which may interfere with transcription and replication. The study investigates the developmental and aging phenot

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Jessica Lindvall 

PROVIDER: E-GEOD-39145 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress