MicroRNA miR-223 constrains lethal inflammation during Mycobacterium tuberculosis infection

ABSTRACT: The molecular mechanisms that control innate cell recruitment during chronic infection and inflammation, such as tuberculosis (TB), are incompletely understood. During TB, myeloid cells infiltrate the lung and sustain local inflammation. We identified microRNA (miR)-223 as one of the most abundant noncoding RNAs in lung parenchyma of TB patients and susceptible mice. MiR-223 controlled lung recruitment of myeloid cells, and consequently, neutrophil-driven lethal inflammation, by directly targeting the chemoattractants CXCL2, CCL3 and IL-6. Our study reveals an essential role for a single miR in TB. Moreover, we identify new targets for and assign novel biological functions to miR-223. By regulating leukocyte chemotaxis via chemoattractants, miR223 is critical for control of TB and probably

ORGANISM(S): Homo sapiens

SUBMITTER: Hans-Joachim Mollenkopf 

PROVIDER: E-GEOD-39163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress