Expression data from asynchronous HUH7 cells

ABSTRACT: During mitosis, RNA polymerase and most transcription factors are excluded from the chromosomes and transcription ceases. The transcriptional re-activation of the genome, following mitosis, requires the re-setting of cell-type specific programs that were initially established during development. However, only about one-fifth of transcription factors are retained on chromosomes throughout mitosis and a subset of these have been shown to facilitate target gene reactivation during mitotic exit. How such “bookmarking” factors bind to chromatin in mitosis and re-activate transcription is central to the stability of transcriptional programs across multiple cell cycles. We compared a diverse set of transcription factors involved in liver differentiation and found different modes of mitotic ch

ORGANISM(S): Homo sapiens

SUBMITTER: Gregory Donahue 

PROVIDER: E-GEOD-39208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress