PML regulates PPAR signaling and fatty acid oxidation in breast cancer

ABSTRACT: Cancer cells exhibit an aberrant metabolism which facilitates more efficient production of biomass, and hence tumor growth and progression. The genetic cues modulating this metabolic switch remain largely undetermined, however. Here we identify a metabolic function for PML which reveals an unexpected role for this bona-fide tumor suppressor in pro-survival activity in breast cancer. We find that PML acts as both a negative regulator of PGC1A acetylation and as a potent activator of peroxisome proliferator-activated receptor (PPAR) signaling and fatty acid oxidation (FAO). We further show that as FAO PML promotes ATP production, inhibits anoikis, and allows luminal filling in 3D basement membrane breast culture models. Furthermore, analysis of breast cancer biopsies reveals that PML is over

ORGANISM(S): Mus musculus

SUBMITTER: BIDMC Genomics 

PROVIDER: E-GEOD-39220 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress