Expression changes in Caenorhabditis elegans xpa-1 mutant

ABSTRACT: Background: The ability of an organism to repair DNA damage is implicated in carcinogenesis and aging. Interestingly expression profiling of Nucleotide Excision Repair (NER) deficient segmental progeroid mice revealed gene expression changes resembling these observed in aged wild type animals. Our previous transcriptional profiling of NER-deficient C. elegans xpa-1 mutant showed overrepresentation of genes involved in lifespan determination and upregulation of several oxidative stress response genes (Fensgard et al. Aging 2010). However, since an independent study performed by Boyd and coworkers (Boyd et al. Mut Res 2010) showed limited number of changes in xpa-1 mutant. Therefore to independently validate that transcriptome modulation does take place in xpa-1 mutants, we performed another

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Jessica Lindvall 

PROVIDER: E-GEOD-39252 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress