Anthracycline resistance in four human cancer cell lines (HGU95A)

ABSTRACT: Reliable clinical tests for predicting cancer chemotherapy response are not available and individual markers failed to correctly predict resistance against anticancer agents. We hypothesized that gene expression patterns attributable to chemotherapy-resistant cells can be used as a classification tool for chemoresistance and provide novel candidate genes involved in anthracycline resistance mechanisms. We contrasted the expression profiles of 4 different human tumor cell lines of gastric, pancreatic, colon and breast origin and of their counterparts resistant to the topoisomerase inhibitors daunorubicin or doxorubicin. We also profiled the sensitive parental cells treated with doxorubicin for 24h. We interrogated Affymetrix HGU133A and U95A arrays independently. We applied two independent

ORGANISM(S): Homo sapiens

SUBMITTER: Balazs Györffy 

PROVIDER: E-GEOD-3927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress