Corticosterone regulation of mRNAs and and corresponding RU486 antagonism in astrocytes in vitro

ABSTRACT: Analysis of mRNA gene expression changes mediated by natural glucocorticoid ligand corticosterone in mouse cortical primary astrocyte cultures; also, parallel analysis of RU486 (mifepristone) antagonism of corticosterone-mediated mRNA changes. Total RNA obtained from astrocyte cultures subjected to 2, 4, or 6 hours of (1) 100nM corticosterone alone, (2) 500nM RU486 alone, or (3) 100nM corticosterone + 500nM RU486 exposure compared to vehicle control astrocyte cultures.

ORGANISM(S): Mus musculus

SUBMITTER: Bradley Carter 

PROVIDER: E-GEOD-39270 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress