Gene expression profiles of non-genotoxic hepatocarcinogens and hepatotoxicants in rat liver

ABSTRACT: Liver tumors in rodents are frequently induced by non-genotoxic carcinogens. These hepatocarcinogens generally activate hepatic nuclear receptors (e.g., CAR and PXR), resulting in a cascade of signals causing modifications in the expression of genes responsible for several processes involved in carcinogenesis. Evaluation of the carcinogenic potential of chemicals is a regulatory requirement but is time-consuming and expensive. Consequently, several short-term in vivo and in vitro approaches, using molecular tools, have been proposed as predictive models for non-genotoxic hepatocarcinogens. The objective of our study was to discriminate between chemicals that are either non-genotoxic hepatocarcinogens or merely hepatotoxicants and also between CAR and PXR modulators on the basis of their ge

ORGANISM(S): Rattus norvegicus

SUBMITTER: Sophie Ludwig 

PROVIDER: E-GEOD-39350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress