Comparison of Zmiz1-induced keratoancanthoma and normal skin

ABSTRACT: Transgenic mice expressing a truncated form of Zmiz1 in the skin develop spontaneous keratoacanthomas. In this experiment, a Cre-inducible transgene expressing a truncated form of Zmiz1 was introduced into mice. Activation of the transgene in these mice was achieved by breeding to K14-Cre transgenic animals. Double transgenic mice formed spontaenous keratoacanthomas with short latency. In this experiment, we generated gene expression profiles for five Zmiz1-induced keratoacanthomas and six normal skin samples.

ORGANISM(S): Mus musculus

SUBMITTER: Adam Dupuy 

PROVIDER: E-GEOD-39360 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress