Proteogenomics of synaptosomal mitochondrial oxidative stress

ABSTRACT: There has been increasing interest in the quantification and characterization of messages and proteins at the synapse, due to its importance in neurodegenerative disease, most notably Alzheimer’s disease. Here, we report the transcriptomic and proteomic changes that occur in synaptosomes from frontal cortices of Sod2 null mice. Constitutively null Sod2 mice were differentially dosed with the synthetic catalytic antioxidant EUK-189, which can extend the lifespan of these mice, as well as uncover or prevent neurodegeneration due to endogenous oxidative stress. This approach facilitated insight into quantification of trafficked messages and proteins to the synaptosome. We used two complementary methods to investigate the nature of the synaptosome under oxidative stress; either whole genome ge

ORGANISM(S): Mus musculus

SUBMITTER: Simon Melov 

PROVIDER: E-GEOD-39372 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress