Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with transcriptional Profile alterations
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Antonino Neri
PROVIDER: E-GEOD-39383 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles.
Mosca Laura L Musto Pellegrino P Todoerti Katia K Barbieri Marzia M Agnelli Luca L Fabris Sonia S Tuana Giacomo G Lionetti Marta M Bonaparte Eleonora E Sirchia Silvia Maria SM Grieco Vitina V Bianchino Gabriella G D'Auria Fiorella F Statuto Teodora T Mazzoccoli Carmela C De Luca Luciana L Petrucci Maria Teresa MT Morabito Fortunato F Offidani Massimo M Di Raimondo Francesco F Falcone Antonietta A Caravita Tommaso T Omedè Paola P Boccadoro Mario M Palumbo Antonio A Neri Antonino A
American journal of hematology 20121009 1
Primary plasma cell leukemia (pPCL) is a rare, yet aggressive form of de novo plasma cell tumor, distinct from secondary PCL (sPCL) which represents a leukemic transformation of pre-existing multiple myeloma (MM). Herein, we performed a comprehensive molecular analysis of a prospective series of pPCLs by means of FISH, single nucleotide polymorphism (SNP) array and gene expression profiling (GEP). IGH@ translocations were identified in 87% of pPCL cases, with prevalence of t(11;14) (40%) and t(1 ...[more]
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