Transcription profiling of rat mammary gland, liver and lung tissues treated with targretin, 9-cis retinoic acid, or 4-hydroxyphenylretinamide

ABSTRACT: A rexinoid, targretin (TRG) and two retinoids, 9-cis retinoic acid (9cRA) and 4-hydroxyphenylretinamide (4HPR) were examined for their effects on gene expression in rat mammary gland, liver, and lung tissues. The chemopreventive effects of these agents have largely been attributed to their ability to interact with retinoic acid receptors (RAR) and/or retinoid X-receptors (RXR). TRG interacts with the RXR receptors. 9cRA interacts with both the RAR and RXR receptors, while 4HPR has a moderate affinity primarily for RAR gamma. Based on previously performed mammary chemoprevention studies, TRG (150mg/Kg diet), 9cRA (100 mg/Kg diet), and 4HPR (792 mg/Kg diet), were administrated to rats continually in their diet for 7 days. Tissue - and agent - specific expression differences were determined b

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yan Lu 

PROVIDER: E-GEOD-3952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress