Mapping Epigenomic Type-Specific Differences Occurring During Hematopoiesis [RNA-Seq]

ABSTRACT: Formation of the blood from self-renewing hematopoietic stem cells to terminal lineages necessarily involves epigenomic modifications of the genome to control regulator and signature gene expression. By analysing the global expression profiles of hematopoietic stem cells (HSCs), in vivo differentiated CD4+ T cells and CD19+ B cells as well as in vitro differentiated erythrocyte precursor cells, we identified hundreds of transcripts showing type-specific expression in these cell types. To understand the epigenomic changes related to tissue-specific expression during HSC differentiation, we examined the genome-wide distribution of H3K4me1, H3K4me3, H3K27me1, H3K27me3, histone variant H2A.Z, chromatin remodeler BRG1, and RNA Polymerase II in the same four cell types, as well as embryonic ste

ORGANISM(S): Homo sapiens

SUBMITTER: Brian Abraham 

PROVIDER: E-GEOD-39537 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress