A mesenchymal stromal cell gene signature for donor age

ABSTRACT: Human aging is associated with loss of function and regenerative capacity. Human bone marrow derived mesenchymal stromal cells (hMSCs) are involved in tissue regeneration, evidenced by their capacity to differentiate into several lineages and therefore are considered the gold standard for cell-based regeneration therapy. Tissue maintenance and regeneration is dependent on stem cells and declines with age and aging is thought to influence therapeutic efficacy, therefore, more insight in the process of aging of hMSCs is of high interest. We, therefore, hypothesized that hMSCs might reflect signs of aging. In order to find markers for donor age, early passage hMSCs were isolated from bone marrow of 61 donors, with ages varying from 17-84, and clinical parameters, in vitro characteristics and

ORGANISM(S): Homo sapiens

SUBMITTER: Nathalie Groen 

PROVIDER: E-GEOD-39540 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress