Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from genetically engineered mouse models (GEMMs)

ABSTRACT: 3 Cell lines from Apc, p53 (AP) GEMMs were compared to 12 cell lines from Apc, Kras, p53 (AKP) GEMMs. Mouse 430 2.0 arrays were used to determine genomic expression differences between the two genotypes (AP and AKP). RNA was extracted from 3 AP and 10 AKP cell lines using the Qiagen RNEasy kit, and hybridized to individual Affymetrix mouse 430 2.0 chips as per manufacturer's instructions

ORGANISM(S): Mus musculus

SUBMITTER: Peter Belmont 

PROVIDER: E-GEOD-39557 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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<h4>Purpose</h4>Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet clinical need. Previously, we described genetically engineered mouse models (GEMM) for sporadic Kras-mutant and non-mutant CRC suitable for preclinical evaluation of experimental therapeutics. To accelerate drug discovery and validation, we sought to derive low-passage cell lines from GEMM Kras-mutant and wild-type tumors for in vitro screening and transplantation into the native colonic environment  ...[more]

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