Membrane Vesicles of a Bacterial Mutualist Mediate Immune Regulation via Dendritic Cells

ABSTRACT: Microbial molecules have evolved to promote transient and/or permanent associations with mammals. Although numerous examples of secretion systems employed by pathogens have been described, mechanisms by which commensal bacteria export molecules during symbiosis remain unknown. The human gut mutualist Bacteroides fragilis produces a capsular polysaccharide (PSA) that directs host immune development. We reveal herein that outer membrane vesicles (OMVs) deliver PSA to dendritic cells (DCs), promoting regulatory T cells and inducing anti-inflammatory cytokines during protection from intestinal disease. In addition, we found that TLR2 signaling by DCs is required for OMV sensing. Following internalization into DCs and engagement of TLR2, OMVs initiate a gene expression program that results in I

ORGANISM(S): Mus musculus

SUBMITTER: Yue Shen 

PROVIDER: E-GEOD-39563 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress