Human prostate carcinoma cell line 22Rv1 overexpressing ESE1

ABSTRACT: Activation of the inflammatory circuits occurs frequently in cancer cells. However the molecular details linking inflammation to transformation and progression are still unknown. In this study we report for the first time, that activation of the ETS factor ESE1 is a key event connecting inflammatory signaling with prostate cancer progression. We report that ESE1 is induced upon IL-1 beta stimulation by NFKB and mediates key transcriptional changes involving cell adhesion, migration and invasion. ESE1 activation in turn induces NFKB transcriptional activation and intranuclear translocation and mediates the transforming phenotypes linked to the activation of IL-1B. Transcriptional signatures and immunohistochemistry revealed that this ESE1-NFKB regulatory circuit also operates in prostate tu

ORGANISM(S): Homo sapiens

SUBMITTER: giovanna chiorino 

PROVIDER: E-GEOD-39668 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress