Histone variant, H2B.Z demarcates the AT-rich promoter regions of the Plasmodium falciparum genome

ABSTRACT: Histone variants are key components of the epigenetic code and evolved to perform specific functions in transcriptional regulation, DNA repair, chromosome segregation and other fundamental processes. H2B.Z is a rare, apicomplexan-specific variant of histone H2B. Here we show that in Plasmodium falciparum H2B.Z localises to euchromatic intergenic regions throughout intraerythrocytic development and together with H2A.Z forms a double-variant nucleosomes subtype. These nucleosomes are enriched in promoters over 3’ intergenic regions and their occupancy generally correlates with the strength of the promoter, but not with its temporal activity. Remarkably, H2B.Z occupancy levels exhibit a clear correlation with the base-composition of the underlying DNA, raising the intriguing possibility that

ORGANISM(S): Plasmodium falciparum 3D7

SUBMITTER: H. Stunnenberg 

PROVIDER: E-GEOD-39702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress