Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Argonaute proteins couple chromatin silencing to alternative splicing


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE39746: Argonaute proteins couple chromatin silencing to alternative splicing (exon array) GSE39748: Argonaute proteins couple chromatin silencing to alternative splicing (RNA IP-Seq) Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Eric Batsche 

PROVIDER: E-GEOD-39749 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Argonaute proteins play a major part in transcriptional gene silencing in many organisms, but their role in the nucleus of somatic mammalian cells remains elusive. Here, we have immunopurified human Argonaute-1 and Argonaute-2 (AGO1 and AGO2) chromatin-embedded proteins and found them associated with chromatin modifiers and, notably, with splicing factors. Using the CD44 gene as a model, we show that AGO1 and AGO2 facilitate spliceosome recruitment and modulate RNA polymerase II elongation rate,  ...[more]

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