MicroRNA expression profiling after short-term exposure to TCDD in zebrafish embryos [miRNA-Seq data]

ABSTRACT: Although many drugs and environmental chemicals are teratogenic, the mechanisms by which most toxicants disrupt embryonic development are not well understood. microRNAs (miRNAs), single-stranded RNA molecules of ~22 nt that regulate protein expression by inhibiting mRNA translation and promoting mRNA sequestration or degradation, are important regulators of a variety of cellular processes including embryonic development and cellular differentiation. We hypothesized that exposure to xenobiotics can alter miRNA expression and contribute to the mechanisms by which environmental chemicals disrupt embryonic development. To test this hypothesis for one well-known teratogen, we exposed zebrafish embryos to DMSO (0.1%) or TCDD (5 nM) for 1 hr at 30 hours post fertilization (hpf) and measured mic

ORGANISM(S): Danio rerio

SUBMITTER: Neelakanteswar Aluru 

PROVIDER: E-GEOD-39808 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress