Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway, and the Activation Is Dependent of Monoamine Oxidases

ABSTRACT: In this study we show that physiological concentrations of tryptamine (TA) lead to induction of cytochrome P4501A1 transcription through an AhR-dependent mechanism. In addition, we show that activation of the AhR by TA requires a functional monoamino oxidase system, suggesting that TA acts as an AhR proligand possibly by converting to a high-affinity AhR ligand. RNA seq was performed from Hepa cells treated with FICZ or TA by SciLifelabs.

ORGANISM(S): Mus musculus

SUBMITTER: Bernward Klocke 

PROVIDER: E-GEOD-39812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress