Microarray Study Reveals Hormone-Modulated Gene Transcription During Human Podocyte Differentiation

ABSTRACT: Glomerular podocytes are highly differentiated kidney cells that constitute one of the key components responsible for removing toxins and metabolic waste while preserving nutrients in the bloodstream in the renal glomerulus. In addition, podocytes contribute significantly to the formation of the glomerular basement membrane and the integrity of the vascular endothelium. Thus, podocyte injury and/or loss of podocytes results in impaired blood filtration and causes many common renal diseases characterized by severe proteinuria (protein in the urine) and hypoalbuminemia (low levels of blood albumin). Small lipopholic molecules such as steroids, fatty acids, prostaglandins and vitamin metabolites control many aspects of animal development, cell proliferation and differentiation, and homeostasi

ORGANISM(S): Homo sapiens

SUBMITTER: Hung-Ying Kao 

PROVIDER: E-GEOD-39823 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress