Hypoxia induces myocardial regeneration in zebrafish

ABSTRACT: Conditional expression of dominant-negative HIF1a in zebrafish cardiomyocytes severely inhibits heart regeneration. To understand more about the mechanism, we performed microarray analysis of wildtype regenerating zebrafish and dnHIF1a regenerating zebrafish to determine which genes are regulated by hypoxia/HIF1a. We amputated both wildtype and dnHIF1a zebrafish and allowed them to regenerate for 7 days, then compared their transcriptomic profile with unamputated wildtype and dnHIF1a zebrafish, respectively.

ORGANISM(S): Danio rerio

SUBMITTER: Chris Jopling 

PROVIDER: E-GEOD-39842 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress