A comprehensive view of the transcriptome during development of the mouse cerebral cortex

ABSTRACT: The complexity of the mature adult brain is a result of both developmental processes and experience-dependent circuit formation. One way to look at the process of brain development is to examine gene expression changes, and previous studies have used microarrays to address this in a global manner. However, the transcriptome is more complex than gene expression levels alone, as both alternative splicing and RNA editing occur to generate a more diverse set of mature transcripts. The aim of the current study was to develop a high-resolution transcriptome dataset of mouse cortical development using RNA sequencing (RNA-Seq), thus assaying exon usage and RNA editing as well as overcoming some of the inherent limitations of microarrays. We found a large number of differentially expressed genes, b

ORGANISM(S): Mus musculus

SUBMITTER: J Raphael Gibbs 

PROVIDER: E-GEOD-39866 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress