Francisella tularensis Schu4 gene expression during infection of mouse spleen

ABSTRACT: Francisella tularensis is classified as a Category A priority pathogen and causes fatal disseminated disease in humans upon inhalation of less than 50 bacteria. Although drugs are available for treatment, they are not ideal because of toxicity and delivery, and in some cases relapse upon withdrawal. We have an ongoing program in the development of novel FabI enoyl-ACP-reductase enzyme inhibitors for Francisella and other select agents. To establish ftFabI in F. tularensis as a clinically relevant drug target, we demonstrated that the enzyme is essential for growth in vitro and that ftfabI is not transcriptionally altered in the presence of exogenous fatty acids. Inhibition of ftFabI results in loss of viability that is not rescued by exogenous fatty acids supplementation. Importantly, whol

ORGANISM(S): Francisella tularensis subsp. tularensis SCHU S4

SUBMITTER: Luke Kingry 

PROVIDER: E-GEOD-39871 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress