Lgr5+ve stem cells in nephrogenesis

ABSTRACT: Multipotent stem cells and their lineage-restricted progeny drive nephron formation within the developing kidney. Validated markers of these early stem/progenitor populations are essential for deciphering their in vivo function and for evaluating their clinical potential for treating adult kidney disease. Here, we document expression of the adult stem cell marker Lgr5 in the developing kidney and assess the stem/progenitor identity of Lgr5+ve cells via in vivo lineage tracing. The appearance and localization of Lgr5+ve cells coincided with that of the S-shaped body around E14. Lgr5 expression remained restricted to cell clusters within developing nephrons in the cortex until P7, when expression was permanently silenced. In vivo lineage tracing identified Lgr5 as a marker of a novel progeni

ORGANISM(S): Mus musculus

SUBMITTER: Rogier Versteeg 

PROVIDER: E-GEOD-39881 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress