Transcription profiling of Drosophila male third instar larva y+ w roX1- roX2-/y vs y+ w roX1+ roX2-/y reveals roX RNAs are required for increased expression of X-linked genes in Drosophila melanogaster males

ABSTRACT: Drosophila males double transcription of their single X chromosome to equalize X-linked gene expression with females, which carry two X chromosomes. Increased transcription requires the Male-Specific Lethal (MSL) complex. One of the primary functions of the MSL complex is thought to be enrichment of H4Ac16 on the male X chromosome, a modification linked to elevated transcription. The roX1 and roX2 RNAs are essential but redundant components of the MSL complex. Simultaneous removal of both roX RNAs reduces MSL X-localization and leads to ectopic binding of these proteins at autosomal sites and to the chromocenter. Some H4Ac16 accumulates at these ectopic sites in roX1- roX2- males, suggesting the possibility of increased expression. The global effect of roX mutations on gene expression

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Xinxian Deng 

PROVIDER: E-GEOD-3990 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress