EBNA1 ChIP-seq and MNase-seq in EBV-positive MUTU cell lines

ABSTRACT: Epstein-Barr Virus (EBV), which is associated with multiple human tumors, persists as a minichromosome in the nucleus of B-lymphocytes and induces malignancies through incompletely understood mechanisms. Here, we present a large-scale functional genomic analysis of EBV. Our experimentally generated nucleosome positioning maps and viral protein binding data were integrated with over 700 publicly available high-throughput sequencing data sets for human lymphoblastoid cell lines mapped to the EBV genome. We found that viral lytic genes are coexpressed with cellular cancer-associated pathways, suggesting that the lytic cycle may play an unexpected role in virus-mediated oncogenesis. Host regulators of viral oncogene expression and chromosome structure were identified and validated, revealing

ORGANISM(S): Human Herpesvirus 5

SUBMITTER: Aaron Arvey 

PROVIDER: E-GEOD-39913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress