Expression data from wild-type and rph1-deleted yeasts

ABSTRACT: Cells respond to environmental signals by alteration of gene expression through action of transcription factors. A JmjC-domain-containing protein Rph1 belongs to the C2H2 zinc finger protein family and functions to repress transcription of PHR1 via histone demethylation. However, additional targets of Rph1 remain largely unknown. Here, we investigate the regulatory network of Rph1 by microarray analyses. More than 75% of Rph1-regulated genes showed increased expression in rph1M-NM-^T, suggesting Rph1 serves as a transcriptional repressor under physiological conditions. The binding motif of Rph1 resembling the STress Response Element (STRE) was over-represented in the promoters of Rph1-repressed genes. In addition, significant proportions of Rph1-regulated genes responded to DNA damage and

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Wan-Sheng Lo 

PROVIDER: E-GEOD-39950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress