A global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps

ABSTRACT: Background: Alternative polyadenylation (APA) is emerging as a widespread mechanism of gene regulation. The usage of APA sites allows a single gene to encode multiple mRNA transcripts with different 3'-untranslated region (3'UTR) lengths. Many disease processes reflect the importance of the regulation of APA site switching. The objective of this study was to explore the profiling of tandem APA sites in nasal polyps compared with nasal uncinate process mucosa. Methods: Sequencing of APA sites (SAPAS) based on second-generation sequencing technology was undertaken to investigate the use of tandem APA sites and identify gene expression patterns in samples from the nasal polyps and nasal uncinate process mucosa of two patients with chronic rhinosinusitis with nasal polyps. The findings of the

ORGANISM(S): Homo sapiens

SUBMITTER: Peng Tian 

PROVIDER: E-GEOD-39957 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress